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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">neurojour</journal-id><journal-title-group><journal-title xml:lang="ru">Неврологический журнал имени Л.О. Бадаляна</journal-title><trans-title-group xml:lang="en"><trans-title>L.O. Badalyan Neurological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2686-8997</issn><issn pub-type="epub">2712-794X</issn><publisher><publisher-name>ФГАУ «НМИЦ здоровья детей» Минздрава России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.46563/2686-8997-2025-6-1-6-12</article-id><article-id custom-type="edn" pub-id-type="custom">vfgzii</article-id><article-id custom-type="elpub" pub-id-type="custom">neurojour-164</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Функциональные и структурные характеристики головного мозга при левосторонней амблиопии у детей</article-title><trans-title-group xml:lang="en"><trans-title>Study of the brain functional and structural characteristics (according to MRI data) in left-sided amblyopia in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0159-781X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбунов</surname><given-names>Александр Валерьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbunov</surname><given-names>Aleksandr V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор мед. наук, профессор, врач-рентгенолог отделения лучевой диагностики ГБУЗ «Морозовская ДГКБ» ДЗМ, 119049, Москва, Россия; профессор кафедры неонатологии ФДПО РНИМУ им. Н.И. Пирогова, 117513, Москва, Россия</p><p>e-mail: agorbunov@morozdgkb.ru</p></bio><bio xml:lang="en"><p>DSc (Medicine), radiologist of the Radiology Department, Morozov Pediatric City Clinical Hospital, Moscow, 119049, Russian Federation; Professor of the Department of Neonatology, Faculty of Further Professional Education, Institute of Continuous Professional Development, Pirogov Russian National Research Medical University, Moscow, 117513, Russian Federation</p><p>e-mail: agorbunov@morozdgkb.ru</p></bio><email xlink:type="simple">agorbunov@morozdgkb.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8272-3648</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горев</surname><given-names>Валерий Викторович</given-names></name><name name-style="western" xml:lang="en"><surname>Gorev</surname><given-names>Valeriy V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Канд. мед. наук, гл. врач ГБУЗ «Морозовская ДГКБ» ДЗМ, 119049, Москва, Россия</p></bio><bio xml:lang="en"><p>MD, PhD, Chief physician of the Morozov Pediatric Municipal Clinical Hospital, Moscow, 119049, Russian Federation</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5698-4251</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Паникратова</surname><given-names>Яна Романовна</given-names></name><name name-style="western" xml:lang="en"><surname>Panikratova</surname><given-names>Yana R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Канд. психол. наук, ст. науч. сотр. лаборатории нейровизуализации и мультимодального анализа ФГБНУ НЦПЗ, 115522, Москва, Россия</p></bio><bio xml:lang="en"><p>PhD (Psychology), senior researcher of the Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, 115522, Russian Federation</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6688-4329</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Томышев</surname><given-names>Александр Сергеевич</given-names></name><name name-style="western" xml:lang="en"><surname>Tomyshev</surname><given-names>Aleksandr S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Канд. биол. наук, ст. науч. сотр. лаборатории нейровизуализации и мультимодального анализа ФГБНУ НЦПЗ, 115522, Москва, Россия</p></bio><bio xml:lang="en"><p>PhD (Biology), senior researcher of the Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, 115522, Russian Federation</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0103-7422</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Заваденко</surname><given-names>Николай Николаевич</given-names></name><name name-style="western" xml:lang="en"><surname>Zavadenko</surname><given-names>Nikolay N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор мед. наук, профессор, зав. кафедрой неврологии, нейрохирургии и медицинской генетики им. акад. Л.О. Бадаляна Института нейронаук и нейротехнологий ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, 117513, Москва</p></bio><bio xml:lang="en"><p>MD, PhD, DSc (Medicine), professor, Head of the Department of neurology, neurosurgery and medical genetics named after academician L.O. Badalyan, Institute of Neuroscience and Neurotechnologies, N.I. Pirogov Russian National Research Medical University, Moscow, 117513, Russian Federation</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-0457-545X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хаценко</surname><given-names>Игорь Евгеньевич</given-names></name><name name-style="western" xml:lang="en"><surname>Khatsenko</surname><given-names>Igor E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Канд. мед. наук, врач-офтальмолог консультативного центра ГБУЗ «Морозовская ДГКБ» ДЗМ, 119049, Москва, Россия</p></bio><bio xml:lang="en"><p>PhD (Medicine), ophthalmologist of the consultative center, Morozov Pediatric Municipal Clinical Hospital, Moscow, 119049, Russian Federation</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6926-3165</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хасанова</surname><given-names>Ксения Андреевна</given-names></name><name name-style="western" xml:lang="en"><surname>Khasanova</surname><given-names>Ksenia A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Канд. мед. наук, врач-рентгенолог, врач-радиолог, зав. отделением лучевой диагностики ГБУЗ «Морозовская ДГКБ» ДЗМ, 119049, Москва, Россия; доцент кафедры лучевой диагностики Сеченовского университета, 119048, Москва, Россия</p></bio><bio xml:lang="en"><p>PhD (Medicine), radiologist, Head of the Radiology Department, Morozov Pediatric Municipal Clinical Hospital, Moscow, 119049, Russian Federation; Associate Professor of the Department of Radiation Diagnostics at Sechenov University, Moscow, 119048,  Russian Federation</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-0213-6093</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбунов</surname><given-names>Михаил Александрович</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbunov</surname><given-names>Mikhail A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Студент 6 курса Медицинского института РУДН, 117198, Москва, Россия</p></bio><bio xml:lang="en"><p>6th year student of the Medical Institute of the Peoples’ Friendship University of Russia named after Patrice Lumumba, Moscow, 117198, Russian Federation</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0649-6663</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедева</surname><given-names>Ирина Сергеевна</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedeva</surname><given-names>Irina S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор биол. наук, руководитель лаборатории нейровизуализации и мультимодального анализа ФГБНУ НЦПЗ, 115522, Москва, Россия</p></bio><bio xml:lang="en"><p>DSc (Biology), Head of the Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, 115522, Russian Federation</p></bio><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБУЗ «Морозовская детская городская клиническая больница Департамента здравоохранения города Москвы»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России (Пироговский Университет)<country>Россия</country></aff><aff xml:lang="en">Morozov Pediatric Municipal Clinical Hospital; N.I. Pirogov Russian National Research Medical University (Pirogov University)<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ «Морозовская детская городская клиническая больница Департамента здравоохранения города Москвы»<country>Россия</country></aff><aff xml:lang="en">Morozov Pediatric Municipal Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ФГБНУ «Научный центр психического здоровья»<country>Россия</country></aff><aff xml:lang="en">Mental Health Research Center<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России (Пироговский Университет)<country>Россия</country></aff><aff xml:lang="en">N.I. Pirogov Russian National Research Medical University (Pirogov University)<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">ГБУЗ «Морозовская детская городская клиническая больница Департамента здравоохранения города Москвы»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)<country>Россия</country></aff><aff xml:lang="en">Morozov Pediatric Municipal Clinical Hospital; I.M. Sechenov First Moscow State Medical University (Sechenov University)<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России (Пироговский Университет); ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» Минобрнауки России<country>Россия</country></aff><aff xml:lang="en">N.I. Pirogov Russian National Research Medical University (Pirogov University); Peoples’ Friendship University of Russia named after Patrice Lumumba<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>04</month><year>2025</year></pub-date><volume>6</volume><issue>1</issue><fpage>6</fpage><lpage>12</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Горбунов А.В., Горев В.В., Паникратова Я.Р., Томышев А.С., Заваденко Н.Н., Хаценко И.Е., Хасанова К.А., Горбунов М.А., Лебедева И.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Горбунов А.В., Горев В.В., Паникратова Я.Р., Томышев А.С., Заваденко Н.Н., Хаценко И.Е., Хасанова К.А., Горбунов М.А., Лебедева И.С.</copyright-holder><copyright-holder xml:lang="en">Gorbunov A.V., Gorev V.V., Panikratova Y.R., Tomyshev A.S., Zavadenko N.N., Khatsenko I.E., Khasanova K.A., Gorbunov M.A., Lebedeva I.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.neuro-journal.ru/jour/article/view/164">https://www.neuro-journal.ru/jour/article/view/164</self-uri><abstract><sec><title>Введение</title><p>Введение. Магнитно-резонансная томография (МРТ), в частности функциональная, является одним из наиболее информативных неинвазивных методов определения структурно-функционального состояния головного мозга, и очевидное направление её развития — изучение возможностей данного подхода в различных областях медицины, в том числе в детской неврологии и офтальмологии.</p><p>Цель работы — определение показателей межполушарной асимметрии по структурным и функциональным показателям и выявление корреляций этих показателей между собой, а также с клиническим характеристиками у детей с левосторонней амблиопией.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В группу для проведения МРТ были включены 20 пациентов с левосторонней амблиопией, однако по итогам проверки качества изображений анализируемая выборка для структурной МРТ составила 17 человек (возраст 6,2–15,1 года; средний возраст 9,5 ± 2,5 года; 9 мальчиков и 8 девочек), для функциональной МРТ покоя — 14 человек (возраст 6,2–15,1 года; средний возраст 9,5 ± 2,5 года; 8 мальчиков и 6 девочек).</p></sec><sec><title>Результаты</title><p>Результаты. Выявлены значимые показатели асимметрии для толщины серого вещества в латеральной затылочной коре, объёма таламуса, показателя локальной согласованности гемодинамического сигнала в нижней латеральной затылочной коре, первичной и вторичной зрительной коре, язычной извилине, хотя эти данные не коррелировали с остротой зрения в глазу с амблиопией.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные результаты могут быть связаны с изменением нейроонтогенеза, но для подтверждения этого требуются дальнейшие исследования.</p><p>Соблюдение этических стандартов. Исследование проводилось согласно принципам Хельсинкской декларации. Все пациенты или их законные представители подписывали добровольное информированное согласие.</p></sec><sec><title>Для корреспонденции</title><p>Для корреспонденции: Горбунов Александр Валерьевич, e-mail: agorbunov@morozdgkb.ru</p></sec><sec><title>Участие авторов</title><p>Участие авторов:Горбунов А.В. — обзор публикаций по теме статьи, сбор и анализ данных, написание текста рукописи;Горев В.В. — написание текста статьи, окончательное утверждение для публикации рукописи;Лебедева И.С. — обзор публикаций по теме статьи, сбор и анализ данных, написание текста рукописи;Заваденко Н.Н. — написание текста статьи, окончательное утверждение для публикации рукописи;Хаценко И.Е. — сбор и анализ данных, написание текста;Паникратова Я.Р. — сбор и анализ данных, написание текста;Томышев А.С. — сбор и анализ данных, написание текста;Хасанова К.А. — сбор и анализ данных, написание текста;Горбунов М.А. — сбор и анализ данных, написание текста.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.</p></sec><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.</p></sec><sec><title>Финансирование</title><p>Финансирование. Исследование не имело спонсорской поддержки.</p></sec><sec><title>Поступила 23</title><p>Поступила 23.12.2024Принята к печати 04.02.2025Опубликована 30.04.2025</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Magnetic resonance imaging (in particular, functional MRI) is one of the most informative non-invasive methods for the analysis of structural and functional brain state, and an obvious direction for its development is to study the possibilities of this approach in various fields of medicine, including pediatric ophthalmology.</p></sec><sec><title>Objective</title><p>Objective. To determine the interhemispheric asymmetry by structural and functional indices and identify its correlations with each other, as well as with clinical characteristics in children with left-sided amblyopia.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Twenty patients with left–sided amblyopia were included in the MRI examination group, however, according to the results of image quality control, the analyzed sample for structural MRI was 17 patients (age from 6.2 to 15.1 years, average aged of 9.5 ± 2.5 years, 9 boys and 8 girls), for functional resting MRI — 14 patients (aged of from 6.2 to 15.1 years, average age of 9.5 ± 2.5 years, 8 boys and 6 girls).</p></sec><sec><title>Results</title><p>Results. Statistically significant asymmetry indices were identified for the thickness of gray matter in the lateral occipital cortex, for the volume of the thalamus, as well as for the local coherence of the hemodynamic signal in the inferior lateral occipital cortex, primary and secondary visual cortices, and lingual gyrus, although these parameters did not correlate with visual acuity in the amblyopic eye.</p></sec><sec><title>Conclusion</title><p>Conclusion. The findings may be associated with changes in neuroontogenesis, although further studies are required to confirm this.</p><p>Compliance with ethical standards. The study was conducted in accordance with the principles of the Declaration of Helsinki. All patients or their legal representatives signed voluntary informed consent.</p></sec><sec><title>Contribution</title><p>Contribution:Gorbunov A.V. — review of publications, data collection and analysis, writing the text of the manuscript;Gorev V.V. — writing the text of the article, final approval for the publication of the manuscript;Lebedeva I.S. — review of publications, data collection and analysis, writing the text of the manuscript;Zavadenko N.N. — writing the text of the article, final approval for the publication of the manuscript;Khatsenko I.E. — data collection and analysis, writing text;Panikratova Ya.R. — data collection and analysis, writing text;Tomyshev A.S — data collection and analysis, writing text;Khasanova K.A. — data collection and analysis, writing text;Gorbunov M.A. — data collection and analysis, writing text.All co-authors are responsible for the integrity of all parts of the manuscript and approval of its final version.</p></sec><sec><title>Acknowledgements</title><p>Acknowledgements. The study had no sponsorship.</p></sec><sec><title>Conflict of interest</title><p>Conflict of interest. The authors declare no conflict of interest.</p></sec><sec><title>Received</title><p>Received: December 23, 2024Accepted: February 4, 2025Published: April 30, 2025</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>амблиопия</kwd><kwd>головной мозг</kwd><kwd>дети</kwd><kwd>магнитно-резонансная томография</kwd><kwd>функциональная магнитно-резонансная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>amblyopia</kwd><kwd>brain</kwd><kwd>children</kwd><kwd>MRI</kwd><kwd>functional MRI</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Горев В.В., Горбунов А.В., Паникратова Я.Р., Томышев А.С., Хаценко И.Е., Кулешов Н.Н. и др. 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