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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">neurojour</journal-id><journal-title-group><journal-title xml:lang="ru">Неврологический журнал имени Л.О. Бадаляна</journal-title><trans-title-group xml:lang="en"><trans-title>L.O. Badalyan Neurological Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2686-8997</issn><issn pub-type="epub">2712-794X</issn><publisher><publisher-name>ФГАУ «НМИЦ здоровья детей» Минздрава России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.46563/2686-8997-2023-4-3-137-143</article-id><article-id custom-type="edn" pub-id-type="custom">aphxkv</article-id><article-id custom-type="elpub" pub-id-type="custom">neurojour-105</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEWS</subject></subj-group></article-categories><title-group><article-title>Диагностика и лечение субтенториальных опухолей головного мозга у детей в начале XXI века</article-title><trans-title-group xml:lang="en"><trans-title>Diagnosis and treatment of subtentorial brain tumors in children at the beginning of the XXI century</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3786-2176</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нганкам</surname><given-names>Леон</given-names></name><name name-style="western" xml:lang="en"><surname>Ngankam</surname><given-names>Leon</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат мед. наук, доц. кафедры неврологии, реабилитации и нейрохирургии ФГБОУ ВО «Тверской государственный медицинский университет Минздрава России», зав. отделением нейрохирургии ГБУЗ «Детская областная клиническая больница», 734003, Тверь.</p><p>e-mail: ngankam@yandex.ru</p></bio><bio xml:lang="en"><p>MD, PhD,  Associate Professor of the Department of Neurology, Rehabilitation and Neurosurgery at the Tver State Medical University of the Ministry of Healthcare of the Russian Federation, Head of the Neurosurgery Department at the Children’s Regional Clinical Hospital, Tver, 734003, Russian Federation.</p><p>e-mail: ngankam@yandex.ru</p></bio><email xlink:type="simple">ngankam@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долгополов</surname><given-names>Игорь С.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolgopolov</surname><given-names>Igor S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чичановская</surname><given-names>Леся В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chichanovskaya</surname><given-names>Lesya V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4165-7677</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусева</surname><given-names>Елизавета В.</given-names></name><name name-style="western" xml:lang="en"><surname>Guseva</surname><given-names>Elizaveta V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Тверской государственный медицинский университет Минздрава России»; ГБУЗ «Детская областная клиническая больница»<country>Россия</country></aff><aff xml:lang="en">Tver State Medical University of the Ministry of Healthcare of the Russian Federation; Children’s Regional Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБОУ ВО «Тверской государственный медицинский университет Минздрава России»<country>Россия</country></aff><aff xml:lang="en">Tver State Medical University of the Ministry of Healthcare of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>19</day><month>10</month><year>2023</year></pub-date><volume>4</volume><issue>3</issue><fpage>137</fpage><lpage>143</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нганкам Л., Долгополов И.С., Чичановская Л.В., Гусева Е.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Нганкам Л., Долгополов И.С., Чичановская Л.В., Гусева Е.В.</copyright-holder><copyright-holder xml:lang="en">Ngankam L., Dolgopolov I.S., Chichanovskaya L.V., Guseva E.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.neuro-journal.ru/jour/article/view/105">https://www.neuro-journal.ru/jour/article/view/105</self-uri><abstract><p>Опухоли головного мозга являются одной из самых грозных патологий, встречающихся у детей, из них наиболее распространены опухоли задней черепной ямки (ЗЧЯ). В обзоре литературы подробно описана клиническая картина опухолей ЗЧЯ, отмечено более раннее появление общемозговой симптоматики (вялости, тошноты, рвоты, головной боли), а не очаговой. Авторы подробно описали симптомы поражения мозжечка при опухоли ЗЧЯ, разделили симптомы поражения полушарий и червя: атаксия, характерная мозжечковая походка свойственны для локализации патологического процесса в черве, а асинергии и понижение мышечного тонуса встречаются при поражении полушарий. Обсуждена клиническая картина гидроцефалии при опухоли ЗЧЯ: быстро увеличивающаяся окружность головы ребёнка, расхождение черепных швов, выбухание родничков, беспокойное поведение и другие признаки. Обоснована необходимость проведения компьютерной томографии и магнитно-резонансной томографии (МРТ) как наиболее значимых методов диаг­ностики, преимущества каждого из них. Отдельное место авторы уделили важности предоперационной коррекции гидроцефалии, использованию системы нейронавигации во время оперативного вмешательства, охарактеризовали основные доступы (доступ через срединную апертуру, трансвермиальный, теловелярный доступы) и способы трепанации черепа, показания к резекционной и костно-пластической трепанации. Обсуждены основные принципы лучевой и химиотерапии, которые проводятся с целью достижения стойкой ремиссии, описаны примерные схемы лечения различных видов опухолей ЗЧЯ. Дополнительно авторами была упомянута необходимость проведения МРТ с контрастированием каждые 3 мес и последующих посещений онколога.</p><sec><title>Участие авторов</title><p>Участие авторов:Нганкам Леон — концепция, написание, редактирование текста;Долгополов И.С. — концепция, написание текста;Чичановская Л.В. — редактирование текста;Гусева Е.В. — написание текста.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.</p></sec><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.</p></sec><sec><title>Финансирование</title><p>Финансирование. Работа не имела спонсорской поддержки.</p></sec><sec><title>Поступила 04</title><p>Поступила 04.07.2023Принята к печати 30.08.2023Опубликована 13.10.2023</p></sec></abstract><trans-abstract xml:lang="en"><p>Cerebral tumors are among the most menacing pathologies occurring in children. Of all the cerebral tumors, posterior cranial fossa tumors have been most widespread in children. The review of literature provides a detailed description of clinical pattern. The sources related about earlier occurrence of non-focal symptoms, rather than focal signs: lack of energy, nausea, vomiting and headache. The authors provided detailed description of cerebellum damage in case of tumors, and split the symptoms of the hemisphere and vermis injuries as ataxy and typical cerebellar gait are common to spot the malignant process in the vermis, whereas dyssynergia and hypomyotonia occur in case of hemisphere damage. The clinical picture of hydrocephalus in tumor pathology of posterior cranial fossa is discussed: rapidly growing child head circumference, separation of cranial sutures, bulging of fontanelle, child restless behavior, and other signs. The need for CT and MRI was substantiated as the most important diagnostic techniques; the benefits of each were also stated. Discussion was given to the clinical pattern of hydrocephalus in tumor pathology of the posterior cranial fossa, and the authors put special emphasis on the significance of presurgical correction of hydrocephalus. The authors mentioned the use of a neuronavigation system during surgical intervention and characterized the major accesses (access via the median aperture, transvermial, telovelar access) and methods of craniotomy, indications for resection and osteoplastic trepanation. This article discussed the basic principles of radio and chemotherapy used to achieve a sustained remission, approximate treatment patterns for various posterior cranial fossa tumors are described. In addition, the authors mentioned the need for MRI with contrast agent each 3 months, and subsequent visits to the specialist in oncology.</p><sec><title>Contributions</title><p>Contributions:Ngankam Leon — concept, writing the text, text editing.Dolgopolov I.S. — concept, writing the text.Chichanovskaya L.V. — text editing.Guseva E.V. — writing the text.All the coauthors — approval of the article final version, responsibility for integrity of all the article parts.</p></sec><sec><title>Acknowledgements</title><p>Acknowledgements. The study had no sponsorship.</p></sec><sec><title>Conflict of interests</title><p>Conflict of interests. The authors declare no conflict of interests.</p></sec><sec><title>Received</title><p>Received: July 04, 2023Accepted:  August 30, 2023Published: October 13, 2023</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>астроцитома</kwd><kwd>медуллобластома</kwd><kwd>менингиома</kwd><kwd>эпиндимома</kwd><kwd>гемангиобластома</kwd><kwd>опухоли задней черепной ямки</kwd><kwd>обзор</kwd></kwd-group><kwd-group xml:lang="en"><kwd>astrocytoma</kwd><kwd>medulloblastoma</kwd><kwd>meningioma</kwd><kwd>ependymoma</kwd><kwd>hemangioblastoma</kwd><kwd>posterior cranial fossa tumors</kwd><kwd>review</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Уткузова М.А., Белоусова М.В., Прусаков В.Ф., Уткузов А.А. Опухоли головного мозга у детей: важность онконастороженности и особенности диагностики с позиции детского невролога. Поволжский онкологический вестник. 2019; 10(1): 7–16. https://elibrary.ru/llyxgq</mixed-citation><mixed-citation xml:lang="en">Utkuzova M.A., Belousova M.V., Prusakov V.F., Utkuzov A.A. Brain tumors of children: the importance of alertness and peculiarities of diagnostics from the position of pediatric neurologist. Povolzhskiy onkologicheskiy vestnik. 2019; 10(1): 7–16. https://elibrary.ru/llyxgq (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Чиссов В.И., Давыдов М.И., ред. Онкология: Национальное руководство. Краткое издание. Москва: ГЭОТАР-Медиа; 2017: 524–33. https://elibrary.ru/rtqwzf</mixed-citation><mixed-citation xml:lang="en">Chissov V.I., Davydov M.I., eds. Oncology: National Guidelines. Short Edition [Onkologiya: Natsional’noe rukovodstvo. Kratkoe izdanie]. Moscow: GEOTAR-Media; 2017: 524–33. https://elibrary.ru/rtqwzf (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Первичные опухоли центральной нервной системы: Клинические рекомендации; 2020.</mixed-citation><mixed-citation xml:lang="en">Primary tumors of the central nervous system: Clinical recommendations; 2020.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Муфазалов Ф.Ф., Аббасова Р.Р., Муфазалова Н.А., Гончарова О.В., Сафина Л.Х., Муфазалова Л.Ф. Современная тактика лечения злокачественных глиом головного мозга и случай полного ответа опухоли на фоне длительного приема баванцизумаба. Злокачественные опухоли. 2017; 7(2): 33–9. https://doi.org/10.18027/2224-5057-2017-2-33-39 https://elibrary.ru/zxjnzt</mixed-citation><mixed-citation xml:lang="en">Mufazalov F.F., Abbasova R.R., Mufazalova N.A., Goncharova O.V., Safina L.Kh., Mufazalova L.F. Modern tactics of treatment of malignant brain glyoma and the case of complete answer of the tumor on long-term treatment with bevacizumab. Zlokachestvennye opukholi. 2017; 7(2): 33–9. https://doi.org/10.18027/2224-5057-2017-2-33-39 https://elibrary.ru/zxjnzt (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Бабичев К.Н., Станишевский А.В., Свистов Д.В. Менингиомы IV желудочка головного мозга. Случай из практики и обзор литературы. Вопросы нейрохирургии им. Н.Н. Бурденко. 2019; 83(3): 77–86. https://doi.org/10.17116/neiro20198303177 https://elibrary.ru/xbsmif</mixed-citation><mixed-citation xml:lang="en">Babichev K.N., Stanishevskiy A.V., Svistov D.V. Fourth ventricle meningiomas. A case report and literature review. Voprosy neyrokhirurgii im. N.N. Burdenko. 2019; 83(3): 77–86. https://doi.org/10.17116/neiro20198303177 https://elibrary.ru/xbsmif (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Шаверский А.В., Орлов Ю.А., Марущенко Л.Л., Моргун В.В. Особенности хирургического лечения астроцитом у детей младшего возраста. Украинский нейрохирургический журнал. 2016; (1): 73–7. https://elibrary.ru/vpwmxl</mixed-citation><mixed-citation xml:lang="en">Shaverskiy A.V., Orlov Yu.A., Marushchenko L.L., Morgun V.V. Features of surgical treatment of cerebellar astrocytomas in children of the first years of life. Ukrainskiy neyrokhirurgicheskiy zhurnal. 2016; (1): 73–7. https://elibrary.ru/vpwmxl (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Guerreiro Stucklin A.S., Grotzer M.A. Chapter 19: Cerebellar tumors. In: Manto M., Huisman T.A.G.M., eds. Handbook of Clinical Neurology. Volume 155. Elsevier; 2018: 289–99. https://doi.org/10.1016/B978-0-444-64189-2.00019-6</mixed-citation><mixed-citation xml:lang="en">Guerreiro Stucklin A.S., Grotzer M.A. Chapter 19: Cerebellar tumors. In: Manto M., Huisman T.A.G.M., eds. Handbook of Clinical Neurology. Volume 155. Elsevier; 2018: 289–99. https://doi.org/10.1016/B978-0-444-64189-2.00019-6</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Louis D.N., Perry A., Wesseling P., Brat D.J., Cree I.A., Figarella-Branger D., et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021; 23(8): 1231–51. https://doi.org/10.1093/neuonc/noab106</mixed-citation><mixed-citation xml:lang="en">Louis D.N., Perry A., Wesseling P., Brat D.J., Cree I.A., Figarella-Branger D., et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021; 23(8): 1231–51. https://doi.org/10.1093/neuonc/noab106</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wisoff J.H., Sanford R.A., Heier L.A., Sposto R., Burger P.C., Yates A.J., et al. Primary neurosurgery for pediatric low-grade gliomas: a prospective multi-institutional study from the Children’s Oncology Group. Neurosurgery. 2011; 68(6): 1548–54. https://doi.org/10.1227/neu.0b013e318214a66e</mixed-citation><mixed-citation xml:lang="en">Wisoff J.H., Sanford R.A., Heier L.A., Sposto R., Burger P.C., Yates A.J., et al. Primary neurosurgery for pediatric low-grade gliomas: a prospective multi-institutional study from the Children’s Oncology Group. Neurosurgery. 2011; 68(6): 1548–54. https://doi.org/10.1227/neu.0b013e318214a66e</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Токарев А.С., Чувилин С.А., Степанов В.Н., Рак В.А. Роль функциональной магнитно-резонансной томографии при удалении опухолей в функционально значимых зонах головного мозга. Нейрохирургия. 2017; (3): 64–9. https://elibrary.ru/ylfptd</mixed-citation><mixed-citation xml:lang="en">Tokarev A.S., Chuvilin S.A., Stepanov V.N., Rak V.A. Role of functional magnetic resonance imaging during removal of tumors in brain eloquent areas. Neyrokhirurgiya. 2017; (3): 64–9. https://elibrary.ru/ylfptd (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Беляев А.Ю., Усачев Д.Ю., Пронин И.Н., Шульц Е.И., Баталов А.И. Анапластические астроцитомы и анапластические олигодендроглиомы головного мозга: современное состояние проблемы. Вопросы нейрохирургии им. Н.Н. Бурденко. 2021; 85(4): 96–102. https://doi.org/10.17116/neiro20218504196 https://elibrary.ru/lrxzga</mixed-citation><mixed-citation xml:lang="en">Belyaev A.Yu., Usachev D.Yu., Pronin I.N., Shul’ts E.I., Batalov A.I. Anaplastic astrocytoma and anaplastic oligodendroglioma of the brain: current state of the problem. Voprosy neyrokhirurgii im. N.N. Burdenko. 2021; 85(4): 96–102. https://doi.org/10.17116/neiro20218504196 https://elibrary.ru/lrxzga (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cherlow J.M., Shaw D.W.W., Margraf L.R., Bowers D.C., Huang J., Fouladi M., et al. Conformal radiation therapy for pediatric patients with low-grade glioma: results from the children’s oncology group phase 2 study ACNS0221. Int. J. Radiat. Oncol. Biol. Phys. 2019; 103(4): 861–8. https://doi.org/10.1016/j.ijrobp.2018.11.004</mixed-citation><mixed-citation xml:lang="en">Cherlow J.M., Shaw D.W.W., Margraf L.R., Bowers D.C., Huang J., Fouladi M., et al. Conformal radiation therapy for pediatric patients with low-grade glioma: results from the children’s oncology group phase 2 study ACNS0221. Int. J. Radiat. Oncol. Biol. Phys. 2019; 103(4): 861–8. https://doi.org/10.1016/j.ijrobp.2018.11.004</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pollack I.F., Agnihotri S., Broniscer A. Childhood brain tumors: current management, biological insights, and future directions. J. Neurosurg. Pediatr. 2019; 23(3): 261–73. https://doi.org/10.3171/2018.10.peds18377</mixed-citation><mixed-citation xml:lang="en">Pollack I.F., Agnihotri S., Broniscer A. Childhood brain tumors: current management, biological insights, and future directions. J. Neurosurg. Pediatr. 2019; 23(3): 261–73. https://doi.org/10.3171/2018.10.peds18377</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Горелышев С.К. Детская нейрохирургия: клинические рекомендации. М.: ГЭОТАР-Медиа; 2016.</mixed-citation><mixed-citation xml:lang="en">Gorelyshev S.K. Pediatric Neurosurgery: Clinical Recommendations [Detskaya neyrokhirurgiya: klinicheskie rekomendatsii]. Moscow: GEOTAR-Media; 2016. (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Измайлов Т.Р., Мельник С.Ю. Сравнительный анализ отдаленных и непосредственных результатов лечения пациентов с медуллобластомой. Вопросы нейрохирургии им. Н.Н. Бурденко. 2021; 85(5): 57–62. https://doi.org/10.17116/neiro20218505157 https://elibrary.ru/himxmr</mixed-citation><mixed-citation xml:lang="en">Izmaylov T.R., Mel’nik S.Yu. Early and long-term outcomes of treatment in patients with medulloblastoma. Voprosy neyrokhirurgii im. N.N. Burdenko. 2021; 85(5): 57–62. https://doi.org/10.17116/neiro20218505157 https://elibrary.ru/himxmr (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Бабичеев К.Н., Станишевский А.В., Свистов Д.В., Аверьянов Д.А., Лакотко Р.С. Хирургическое лечение опухолей IV желудочка. Сравнительный анализ эффективности и безопасности срединного и теловелярного доступов. Нейрохирургия. 2018; 20(4): 10–9. https://doi.org/10.17650/1683-3295-2018-20-4-10-19 https://elibrary.ru/ytgdvz</mixed-citation><mixed-citation xml:lang="en">Babicheev K.N., Stanishevskiy A.V., Svistov D.V., Aver‘yanov D.A., Lakotko R.S. Surgical resection of fourth ventricular tumors. Comparison of the efficiency and safety of telovelar and median aperture approaches to the fourth ventricle. Neyrokhirurgiya. 2018; 20(4): 10–9. https://doi.org/10.17650/1683-3295-2018-20-4-10-19 https://elibrary.ru/ytgdvz (in Russian)</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen A.R. Brain tumors in children. N. Engl. J. Med. 2022; 386(20): 1922–31. https://doi.org/10.1056/nejmra2116344</mixed-citation><mixed-citation xml:lang="en">Cohen A.R. Brain tumors in children. N. Engl. J. Med. 2022; 386(20): 1922–31. https://doi.org/10.1056/nejmra2116344</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ater J.L., Zhou T., Holmes E., Mazewski C.M., Booth T.N., Freyer D.R., et al. Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children’s Oncology Group. J. Clin. Oncol. 2012; 30(21): 2641–7. https://doi.org/10.1200/jco.2011.36.6054</mixed-citation><mixed-citation xml:lang="en">Ater J.L., Zhou T., Holmes E., Mazewski C.M., Booth T.N., Freyer D.R., et al. Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children’s Oncology Group. J. Clin. Oncol. 2012; 30(21): 2641–7. https://doi.org/10.1200/jco.2011.36.6054</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Lassaletta A., Scheinemann K., Zelcer S.M., Hukin J., Wilson B.A., Jabado N., et al. Phase II weekly vinblastine for chemotherapy-naïve children with progressive low-grade glioma: A Canadian pediatric brain tumor consortium study. J. Clin. Oncol. 2016; 34(29): 3537–43. https://doi.org/10.1200/jco.2016.68.1585</mixed-citation><mixed-citation xml:lang="en">Lassaletta A., Scheinemann K., Zelcer S.M., Hukin J., Wilson B.A., Jabado N., et al. Phase II weekly vinblastine for chemotherapy-naïve children with progressive low-grade glioma: A Canadian pediatric brain tumor consortium study. J. Clin. Oncol. 2016; 34(29): 3537–43. https://doi.org/10.1200/jco.2016.68.1585</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Pfister S., Janzarik W.G., Remke M., Ernst A., Werft W., Becker N., et al. BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. J. Clin. Invest. 2008; 118(5): 1739–49. https://doi.org/10.1172/jci33656</mixed-citation><mixed-citation xml:lang="en">Pfister S., Janzarik W.G., Remke M., Ernst A., Werft W., Becker N., et al. BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. J. Clin. Invest. 2008; 118(5): 1739–49. https://doi.org/10.1172/jci33656</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Banerjee A., Jakacki R.I., Onar-Thomas A., Wu S., Nicolaides T., Young Poussaint T., et al. A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study. Neuro Oncol. 2017; 19(8): 1135–44. https://doi.org/10.1093/neuonc/now282</mixed-citation><mixed-citation xml:lang="en">Banerjee A., Jakacki R.I., Onar-Thomas A., Wu S., Nicolaides T., Young Poussaint T., et al. A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study. Neuro Oncol. 2017; 19(8): 1135–44. https://doi.org/10.1093/neuonc/now282</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Bouffet E., Geoerger B., Moertel C., Whitlock J.A., Aerts I., Hargrave D., et al. Efficacy and safety of trametinib monotherapy or in combination with dabrafenib in pediatric BRAF V600-mutant low-grade glioma. J. Clin. Oncol. 2023; 41(3): 664–74. https://doi.org/10.1200/jco.22.01000</mixed-citation><mixed-citation xml:lang="en">Bouffet E., Geoerger B., Moertel C., Whitlock J.A., Aerts I., Hargrave D., et al. Efficacy and safety of trametinib monotherapy or in combination with dabrafenib in pediatric BRAF V600-mutant low-grade glioma. J. Clin. Oncol. 2023; 41(3): 664–74. https://doi.org/10.1200/jco.22.01000</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Manoharan N., Liu K.X., Mueller S., Haas-Kogan D.A., Bandopadhayay P. Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era. Neoplasia. 2023; 36: 100857. https://doi.org/10.1016/j.neo.2022.100857</mixed-citation><mixed-citation xml:lang="en">Manoharan N., Liu K.X., Mueller S., Haas-Kogan D.A., Bandopadhayay P. Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era. Neoplasia. 2023; 36: 100857. https://doi.org/10.1016/j.neo.2022.100857</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
